| REVIEW ARTICLE |
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| Year : 2015 | Volume
: 2
| Issue : 3 | Page : 161-166 |
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The role of Vitamin D in obesity and inflammation at adipose tissue
Wysllenny Nascimento de Souza, Ligia Araujo Martini
Department of Nutrition, School of Public Health, University of São Paulo, Brazil Ave. Dr. Arnaldo, 715. Zip code: 01246 904, São Paulo, Brazil
Correspondence Address:
Wysllenny Nascimento de Souza
Ave. Prof Mello de Moraes, 1235, BL G Apto 409. Zip Code: 05508 030, São Paulo
Brazil
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2347-9906.162350
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The prevalence of obesity and vitamin D deficiency has increased in the last decade, becoming pandemics. In obesity, macrophage accumulation occurs in the adipose tissue. This is associated with a low-grade chronic inflammation and leads to the release of inflammatory cytokines. Vitamin D was found to have anti-adipogenic activity and may exert immunoregulatory effects as well as reduce the adipose tissue inflammation. Recent studies suggest that vitamin D and vitamin D receptor (VDR) play an important role in adipose tissue whereas the expression of genes of the 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) and VDR were demonstrated in human adipocytes. Growing evidence suggests vitamin D also plays a role in the type of preadipocytes, and the proneness to the inflammatory process.
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