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Year : 2014  |  Volume : 1  |  Issue : 4  |  Page : 250

Research Digest

Director, Medical Research Centre, Kasturba Health Society, Ville Parle (W), Mumbai, Maharashtra, India

Date of Submission04-Dec-2014
Date of Web Publication11-Dec-2014

Correspondence Address:
Ashok D. B. Vaidya
Medical Research Centre, Kasturba Health Society, Ville Parle (W), Mumbai 400 056, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2347-9906.146806

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How to cite this article:
Vaidya AD. Research Digest. J Obes Metab Res 2014;1:250

How to cite this URL:
Vaidya AD. Research Digest. J Obes Metab Res [serial online] 2014 [cited 2021 May 15];1:250. Available from: https://www.jomrjournal.org/text.asp?2014/1/4/250/146806

Vetter ML, Amaro A, Volger S. Nutritional management of type 2 diabetes mellitus and obesity and pharmacologic therapies to facilitate weight loss. Postgrad Med 2014;126:139-52.

Patients with T2 diabetes mellitus often lack continued counseling and monitoring by dieticians or diabetes educators, as to their dietary intake. The article emphasized that, for medical nutrition therapy (MNT) the recommendation need to be flexible, individualized and pursued closely. The nature of carbohydrate (low glycemic index), fats intake (mono- and polyunsaturated) need to be titrated as per the degree of weight loss needed or, maintenance of the body weight (BW). Behavioral therapy is vital to reinforce healthy lifestyle - exercise, diet, stress-management, etc., Significant benefits result from a modest loss in BW (5-10%). A revolution in HbA 1 C of around 0.5% can occur with the loss of 4.5 kg of BW. Anti-obesity drugs may augment the MNT. Physicians and diabetologist should ensure that the counseling and dietary-lifestyle changes continue.

Kuhl ES, Clifford LM, Bandstra NF, Filigno SS, Yeomans-Maldonado G, Rausch JR, et al. Examination of the association between lifestyle behavior changes and weight outcomes in preschoolers receiving treatment for obesity. Health Psychol 2014;33:95-8.

There are insufficient studies on the outcome of obesity management in preschool children (2-5 years). This is so, despite around 12.5% of the group reported to be obese/overweight. Even the interventional targets are relatively ill-defined. The study was aimed at examining the effects of weight control intervention and the predictability of lifestyle changes on body mass index (BMI). BMI, diet recall, physical activity, TV use, etc., were recorded basically and after 6 months in 30 preschool children. A linear regression approach was applied. The data showed that notwithstanding the decline in TV use and of colas the reduction in the total calorie intake only predicted significant reductions in BMI. The authors concluded that achieving healthy calorie goal is most important component of the interventional MNT therapy.

Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, et al. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab 2014;20:670-7.

Dr. David Mangelsdorf and Dr. Steven Kliewer from UT Southwestern Medical Center, show that fibroblast growth factor 21 (FGF21) acts directly on the brain to regulate obesity. Presence of βKlotho, the obligate coreceptor for FGF21, in the nervous system is important for these effects. Corticotropin-releasing factor (CRF) in brain gets activated through FGF21. CRF in turn stimulates the nervous system, activating brown adipose tissue (BAT). BAT burns fat and generates body heat.

Hurler syndrome treated with cord blood transplant

The team of physicians at National Taiwan University Hospital via a cord blood transplant, successfully treated Nen-Nen (1 st in the nation) for Hurler syndrome that is a rare metabolic disorder. It is a type of mucopolysaccharidoses in which individuals cannot break down long chains of sugar molecules called glycosaminoglycans, resulting in a series of symptoms including mental degeneration, large cranial size, heart problems and joint stiffness. As the life expectancy of such untreated children is about 5-10 years, this success story comes as a ray of hope for them, if they find a suitable donor and undergo the transplant procedure before the age of 2 years.

Available from: http://www.taipeitimes.com/News/taiwan/archives/2014/10/08/2003601591. [Last accessed on 2014 Oct 29].


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