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ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 4  |  Page : 209-213

A comparative, randomized pilot study of insulin glargine versus insulin detemir as add-on therapy in uncontrolled type 2 diabetic patients


1 Department of Pharmacology, MGM Medical College, Aurangabad, Maharashtra, India
2 Consultant-Medical Communication Plasma Medical Services, Nerul, Navi Mumbai, India

Correspondence Address:
Deepak S Bhosle
Department of Pharmacology, MGM Medical College, Aurangabad, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2347-9906.146797

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Objective: The aim was to compare the efficacy and safety of insulin glargine versus insulin detemir as add-on therapy in type 2 diabetes patients inadequately controlled on oral hypoglycemic agents. Materials and Methods: A total of 40 patients were randomized in two groups to receive either insulin glargine or insulin detemir in addition to their current medications. The dose of insulin was titrated to achieve glycosylated hemoglobin (HbA1c) targets of <7%. After randomization of patients, oral hypoglycemic medications were unchanged. Patients were followed for 24 weeks. The number of patients achieving target HbA1c (<7%), mean reduction in fasting and predinner blood glucose and number of hypoglycaemic events were observed in both the groups. Results: Significantly more number of patients in the glargine group (60%) achieved target HbA1c of <7% (p < 0.05) compared with detemir (25%) group. Mean reductions in the fasting and predinner blood glucose were similar in both the group (p > 0.05). Significantly less number of hypoglycemic episodes were observed in glargine group (14 versus 2). Conclusion: In uncontrolled type 2 diabetes patients, insulin glargine is better suited for achieving glycemic control compared with insulin detemir with less incidence of hypoglycemia.


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