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REVIEW ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 3  |  Page : 161-166

The role of Vitamin D in obesity and inflammation at adipose tissue


Department of Nutrition, School of Public Health, University of São Paulo, Brazil Ave. Dr. Arnaldo, 715. Zip code: 01246 904, São Paulo, Brazil

Correspondence Address:
Wysllenny Nascimento de Souza
Ave. Prof Mello de Moraes, 1235, BL G Apto 409. Zip Code: 05508 030, São Paulo
Brazil
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2347-9906.162350

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The prevalence of obesity and vitamin D deficiency has increased in the last decade, becoming pandemics. In obesity, macrophage accumulation occurs in the adipose tissue. This is associated with a low-grade chronic inflammation and leads to the release of inflammatory cytokines. Vitamin D was found to have anti-adipogenic activity and may exert immunoregulatory effects as well as reduce the adipose tissue inflammation. Recent studies suggest that vitamin D and vitamin D receptor (VDR) play an important role in adipose tissue whereas the expression of genes of the 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) and VDR were demonstrated in human adipocytes. Growing evidence suggests vitamin D also plays a role in the type of preadipocytes, and the proneness to the inflammatory process.


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