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ORIGINAL ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 3  |  Page : 149-151

Role of α-glucosidase inhibitors (Voglibose) on postprandial blood glucose level in alloxan induced diabetic rabbits


Department of Pharmacology, IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India

Correspondence Address:
Manas Ranjan Naik
Department of Pharmacology, IMS and SUM Hospital, K 8, Kalinga Nagar, B.O. Ghatikia, Bhubaneswar 751 003, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2347-9906.141141

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Background: α glucosidase inhibitors like Acarbose ® , Voglibose ® and Miglitol ® inhibit the action of α glucosidase, and that reduces postprandial hyperglycemia. It is worthwhile to study the dose-response and comparative efficacy of Voglibose ® . Aim of the Study: The aim of the study is to study the effect of graded doses of Voglibose ® on impaired glucose tolerance and to compare it with a placebo and standard drug (metformin). Materials and Methods: In this study, 24 rabbits were divided into six groups with four rabbits per group. In all the groups diabetes was induced by administering alloxan. Group-1 was considered as a diabetic control. Group II, III, and IV were treated with Voglibose ® 0.25 mg, 0.5 mg, and 1 mg/kg/day. Group V rabbits were treated with metformin 50 mg/kg/day, and Group VI ones were treated with a combination of Voglibose ® (1 mg/kg/day) and metformin (50 mg/kg/day). Results: The graded doses of Voglibose ® showed a dose response. Voglibose ® alone and with metformin were found to control PPBS at 1 h and 2 h (P < 0.01). There was also a decrease in the fasting glucose over a period of 3 weeks. Voglibose ® (0.25 mg/kg) was equivalent to metformin (150 mg/kg). However, the same dose of metformin was significantly less effective than Voglibose ® at the doses of 0.5 mg/kg and 1.0 mg/kg. Conclusion: The response to Voglibose ® (1 mg/kg) on the postprandial hyperglycemia is better than with metformin. However, when Voglibose and metformin were combined the response was enhanced


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